Oswego's undergraduate programs allow students to explore their interests from A (accounting) to Z (zoology). There are more than 60 academic majors as well as 10 cooperative degree programs that allow students to complete joint degrees with other institutions. Students can also complete a secondary concentration in nearly as many academic minors.

Along with their major/minor program coursework, students are required to complete a set of coursework in General Education, a program that provides the foundation for a liberal arts education.

Students complete their major, general education and optional minor requirements as part of a complete academic study plan that meets overall graduation requirements.